Background: One of the risk factors of congestive heart failure that still under\ninvestigations is hyperuricemia. Itâ??s still debatable whether itâ??s an independent\nrisk factor or itâ??s just a consequence of other disorders associated\nwith cardiovascular diseases like hypertension, diabetes and dyslipidemia.\nObjective: The aim of our study is to elucidate whether in patients with heart\nfailure serum uric acid level correlates with left ventricular ejection fraction\nsupporting the possibility that the detection of progressive hyperuricemia in\nthese patients may be an indicator of deteriorating cardiac function. Methods:\nWe conducted a prospective study that included 124 studied patients\nand 26 apparently healthy persons at Coronary care unit and Internal Medicine\nDepartment at Sohag University Hospitals. Studied populations were\nclassified into; * Group â??Iâ?: newly diagnosed heart failure, * Group â??IIâ?: decompensated\nheart failure on regular treatment, * Group â??IIIâ?: decompensated\nheart failure but stopped their treatment from three months, Group\nâ??IVâ?: control group, healthy and age-matched subjects. We studied the association\nbetween left ventricular ejection fraction, the severity of congestive\nheart failure and the serum uric acid levels and the well-known conventional\nrisk factors. Results: The main finding was the significantly higher mean serum\nuric acid levels in patients with congestive heart failure versus apparently\nhealthy persons with â??P value = 0.02â?. When we adjusted the serum uric acid\nwith other significant risk factors in the univariate analysis which were age,\ngender and smoking, serum uric acid was an independent risk factor â??P value\n= 0.04â?. There was a significant correlation between serum uric acid level and\nthe severity of congestive heart failure â??P value < 0.001, correlation coefficient\n= 0.35â?. High rates of serum uric acid levels were recorded in patients with\nreduced ejection fraction. A uric acid level of 8.45 mg/dl was found to be the\nmost appropriate cut-off point with the sensitivity 62% and the specificity\n78.5%. Conclusion: Higher serum uric acid levels are significantly correlated\nwith the severity of congestive heart failure and left ventricular ejection fraction.\nSerum uric acid is an independent risk factor for congestive heart failure.
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